Your blood has many different kinds of cells, which include white blood cells, red blood cells, as well as platelets. General practitioners order blood examinations as they want to study these cells for symptoms of medical issues.

Complete Blood Count or CBC for short is the most common assessment that general practitioners run to know if you have normal blood count. Complete Blood Count is an umbrella term for a sequence of tests which look at definite types of cells in your blood.

One of the many tests done during a complete blood count is MPV or mean platelet volume test. This test measures the normal size of your platelets. Mean Platelet Volume test is closely associated with a platelet count examination, which measures the number of platelets in the body.

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What is Platelet?

Platelet is a small blood cell that plays a very important function in blood clotting. Like for instance, if you accidentally cut yourself, platelets stick together to end the bleeding. In most cases, the abnormalities of your platelet can be an indication of a bleeding turmoil or other medical issues.

Having a high mean platelet volume does not mean anything. It must be interpreted in the context of other complete blood count results, like platelet count.

What is the Normal Mean Platelet Volume?

In most cases, 7.5 to 11.5 levels of femtoliters is the normal average for MPV. However, this range is subject to a lot of other factors.

There are lots of factors that should be considered on how to know the best range of MPV for specific individuals. One of these factors includes geographical factors of the place where the individual lives. Like for instance, people living in Mediterranean area have shown to exhibit a high mean platelet volume than people living in other geographical regions.

Mean Platelet Volume is affected by Cardiovascular Factors

Cardiovascular risk factors including hypertension and smoking can influence mean platelet volume, based on the impenetrable factors such as low-grade inflammation. There’s a confirmed connection between the risk of thrombosis and high mean platelet volume.

High mean platelet volume is linked to diverse established risks, cerebrovascular and cardiovascular disorders, and low-grade inflammatory illnesses prone to arterial and venous thrombosis.

Also, remember that many factors can affect your mean platelet volume, like living at a high elevation or following a stern workout routine. You have to ensure you go over your test results with the physician to get the full picture.

Mean Platelet Volume Shows How Reactive Your Platelets Are

MPV can be utilized to show how large and reactive your platelet can be. It is an outcome of platelets turnover level.

A high mean platelet volume is a sign of reactive and larger platelets that is because of the outcome of augmented platelet turnover. That will signify risk for vascular mortality, which includes myocardial infarction.  People with elevated mean platelet volume can experience blood disorders that can lead to death.

Also Read: How do platelets aid in the healing of cuts?

Mean Platelet Volume Is Valuable as Prognostic Marker

MPV is also helpful in the evaluation of the results of clinical conditions like ischemic bowel disease and stroke. It is utilized as a prognostic marker to prove whether the results of patients suffering from these conditions will be unfavorable or favorable.

Research shows that patients suffering from a higher incidence of the previous stroke are the one who has an MPV of over 9.4FI. An elevated mean platelet volume is typically seen as a sign of poor results in patients experiencing these conditions.

How Will You Know If You Have High Mean Platelet Volume?

MVP testing will help you determine if you have high mean platelet volume. This test is a simple and easy process. Usually, it is performed as part of the yearly checkup with the general practitioner.

A phlebotomist, (the one that undergoes training in drawing blood) will bind a tourniquet in your arm to puff up your veins.  Then he will insert a needle into your vein to get blood. Even if the pain is minimal, still you might have some tenderness and bruise that will last for a couple of days.

What if you have a High MPV? What is the meaning of this?

A high mean platelet volume signifies that your platelets are higher than the normal. Sometimes this is an indication that your body is generating lots of platelets. These platelets are generated in your bone marrow. It is released into your bloodstream.

If you have a high mean platelet level or a low platelet level, it shows that your bone marrow is producing platelets fast. That might be due to the older platelets which are being destroyed. Therefore, your bone marrow is trying to give back.

What are the Causes of High Mean Platelet Volume?

Many causes trigger the augmentation of mean platelet volume. Some of the most common reasons behind the elevation of MPV are as follows:


Increased mean platelet volume is linked to the activation of platelet that can occur when platelet bumps into tumor byproducts. However, having high mean platelet volume does not signify that you have this condition. On the other hand, if the family has a history of cancer or any risk factors, your general practitioner may do some testing to assure there are no other symptoms.

Once you have cancer, an augment mean platelet volume might cause a symptom; it depends on blood test results. Platelet is responsible for spreading cancer to various parts of your body and encourages tumor growth.

An augment in mean platelet volume suggested the increased production of platelet that is related to reduce survival tests in various kinds of cancer, which include:

  • Ovarian cancer
  • Endometrial cancer
  • Colon cancer
  • Kidney cancer
  • Stomach cancer
  • Breast cancer
  • Lung cancer
  • Pancreatic cancer

Always keep in mind that Mean Platelet Volume refers to platelet’s sizes, not the actual amount of them. Mean Platelet Volume alone does not mean you have any of these conditions.

If you are worried about cancer, you have to be aware of these early warning signs:

  • Changes in breast
  • Changes in skin
  • Lump under or on your skin
  • Thickening skin
  • Bowel habit changes
  • Recurrent cough or hoarseness
  • Painful or difficult urination
  • Trouble swallowing
  • Appetite changes
  • Weight loss or gain for no reason
  • Stomach pain
  • Night sweat even if it cold
  • Unusual bleeding
  • Discharge in stool or urine
  • Feeling very tired and weak

Primary Thrombocytosis

This condition happens when lots of platelets are being made. Primary Thrombocytosis is caused by primary conditions that set off the overproduction. Anemia, infection, cancer, blood loss, or surgery can lead to thrombocytosis. Inflammatory illnesses like connective tissue, inflammatory bowel disease rheumatoid arthritis.

Primary Thrombocythemia Causes

Until now, the exact cause of this condition is unidentified. Research conducted b MPN Research Foundation, about ½ of people with this condition experience gene mutation in the JAK2 gene. This type of gene is in charge of creating a protein, which promotes the division and growth of cells.

Once the platelet level is high because of a specific condition or disease, it is called reactive or secondary thrombocytosis. Primary thrombocythemia, however, is rare. This condition is common amongst people especially women over the age of 50. But, this medical condition can also happen to younger people.

Also See: What factor stimulates platelet formation?

Signs of Primary Thrombocythemia

Normally primary thrombocythemia does not cause any signs. Blood clotting might be the primary indication that there is something wrong. A blood clot can occur in many parts of the body; however, they are more likely to develop in your brain, feet, and hands.  The signs of blood clot differ depending on where it is located. Generally, the signs of blood clot include:

  • Headache
  • Weakness
  • Fainting
  • Dizziness or lightheadedness
  • Numbness
  • Tingling in hands and feet
  • Throbbing, redness and blazing pain in hands and feet
  • Chest pain
  • Changes in vision
  • A bit enlarged spleen
  • In seldom cases, the condition can lead to bleeding. This might happen in the type of:
  • Nosebleeds
  • Easy bruising
  • Bleeding from mouth or gums
  • Bloody stool and urine
  • Chronic Myelogenous Leukemia

This condition happens due to the faulty gene which causes on overdevelopment of cells. The stage of chronic myelogenous slowly progresses and last a long period of time with a small number of symptoms. Once this condition is not diagnosed and left untreated, this moves into a hastened stage when the cells grow fast and lead to bone pain, fever, as well as swollen spleen. Once this condition is still untreated in spite of these symptoms, it will develop to a third phase, or also known as blast crisis. Blast crisis is when your bone marrow stops working and bleeding and infection takes place.

Approach Considerations

The aims of CML treatment are threefold and have modified markedly in the previous years. Treatments include:

  • Hematologic remission (physical examination and normal CBC or complete blood count).
  • Cytogenetic remission
  • Molecular remission
  • Polycythemia Vera

PV is a rare condition wherein the bone marrow generates excessive blood cells, which include platelets. Dizziness, difficulty breathing, redness in skin and headaches are symptoms. This condition happens due to blood clotting and thick blood.  PV enhances the peril of blood clots forming, which can cause heart attacks and strokes. That can also lead to other conditions such as acute myelogenous leukemia and myelofibrosis.

Other common symptoms of Polycythemia Vera

  • Bruising or bleeding, usually minor
  • Fatigue
  • Weakness
  • Blurred vision
  • Blurred vision
  • Too much sweating
  • Painful inflammation of one joint, most of the time the big toe
  • Bloating in the left upper stomach because of the enlarged spleen
  • Unexplained weight loss
  • Fevers


PV is one cluster of blood cancers named myeloproliferative neoplasms. It happens once a mutation in the gene causes trouble with the production of blood cell. Usually, the body controls the number of three kinds of blood cells an individual has, white blood cells, red blood cells as well as platelets. However, in PV, bone marrow generates a higher number of blood cells.

The mutation which causes PV believed to affect a protein switch, which tells the cell to grow. A lot of people with PV have this gene mutation.

What are the Risks of High MPV?

It is very important to keep your mean platelet volume normal. High MPV can lead to various conditions such as:

High Mean Platelet Volume Results in Platelets Destruction

High MPV with a low level of platelet leads to a condition which results in massive devastation of platelets in your blood. Conditions which might come up takes account of immune thrombocytopenia. It is a medical condition wherein your immune system abnormally combats the platelets once formed, as a result of destroying them.

During pregnancy, a medical condition popularly called as pre-eclampsia might be experienced. Pre-eclampsia is a medical state wherein your blood pressure is elevated to a higher level. However, this condition gets well after giving birth, and this gets normal after weeks.

High Mean Platelet Volume Might Result in Blood Clumping

Abnormal mean platelet volume does not only help spot underlying conditions, which merit further tests or confirm medical states but are also pinpointing the danger in itself.

Like for instance, a high mean platelet volume shows that the level of platelets in your blood is higher than normal. That implies that your platelets tend to clump and clotting. This kind of condition puts you at risk for various medical issues like stroke, cardiovascular as well as thrombosis.  In most cases, your doctor might prescribe aspirin. This drug can put clumping off the platelets to develop clots.


Mean Platelet Volume is a calculated measurement of the normal size of platelets in your blood and is usually included in CBC tests. Since the normal average size is bigger when your body is generating increased amounts of platelets, the test results of MPV can be utilized to make inferences on the production of platelet in bone marrow.

High MPV is due to the destruction of platelets. Some of the causes of high MPV are mentioned above. You need to be aware of these causes, and once you notice any signs, it is highly advisable to go to your doctor for a series of tests immediately.

What Kind of Platelet Problem Do You Have?

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